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DeCS
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Descriptor English:
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Neural Cell Adhesion Molecule L1
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Descriptor Spanish:
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Molécula L1 de Adhesión de Célula Nerviosa
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Descriptor Portuguese:
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Molécula L1 de Adesão de Célula Nervosa
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Tree Number:
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D12.776.395.550.200.250.520.578
D12.776.543.550.200.250.520.578
D23.050.301.350.250.520.578
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Definition English:
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A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination. |
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History Note English:
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2003; use NEURAL CELL ADHESION MOLECULE L1 (NM) 1983-2002; for NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1992-2002; for CALL PROTEIN use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1999-2002; for NILE PROTEIN use LEUCKCYTE L1 ANTIGEN COMPLEX (NM) 1996-2002
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Allowable Qualifiers English:
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Record Number:
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37447
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Unique Identifier:
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D039842
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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